Keywords Zinc Sulfate Semisynthetic Derivative Lymphogranuloma Venereum Introduction Tetracyclines are bacteriostatic antibiotics that are considered broad-spectrum antibiotics because they are active against a wide range of aerobic and anaerobic gram-positive and gram-negative bacteria, and against other microorganisms, including Rickettsia, Chlamydia and Plasmodium spp
head-to-head clinical trials are needed fora direct 0149-2918/05/$19
Furthermore, minocycline's anti-infectious potency aligns closely with that of other tetracyclines
Several animal experiments and clinical trials have reported that minocycline exert anti-apoptotic, anti-inflammatory and antioxidant effects in treating neurodegenerative diseases
The PICO (patient/population, intervention, comparison and outcomes) framework was used to search 5 databases aiming to identify randomized controlled trials that used minocycline as an The study was conducted in Germany and designed as a multicenter double-blind randomized clinical trial (RCT) of 200 mg/d minocycline treatment over a course of 6 weeks with a 6-month follow-up
Secondary outcomes included days in delirium during Introduction Due to the anti-inflammatory, antioxidant and anti-apoptotic properties of minocycline, clinical trials have evaluated the potential of this drug to treat several psychiatric and neurological disorders, including major depressive disorder, schizophrenia, bipolar disorder, stroke and amyotrophic lateral sclerosis
This systematic review aimed to evaluate the efficacy and tolerability of minocycline in patients having depression with or without treatment-resistance
Methods
Minocycline is also used for the treatment of acne and rheumatoid arthritis
," is off-patent but currently not subject to generic competition First Clinical Trial
The subjects are then contacted daily to check their level of pain
Forty-three patients received minocycline for 8 days from the evening before surgery, and 42 patients received a placebo
For example, while at Lederle Labs, I worked on a new indication for MINOCIN ®-namely, treatment of moderate-to-severe periodontitis
PMID: 6418928 No abstract available
Some preliminary data also suggest that minocycline may be useful in patients with schizophrenia
However, this medicine will not work for colds, flu, or other virus infections
An oral dose of 200 mg of minocycline was administered at various times within a 6-24-h therapeutic window and repeated daily for 5 days
ANIMAL PHARMACOLOGY AND TOXICOLOGY
To the Editor: Most obsessive-compulsive disorder (OCD) patients treated with serotonin reuptake inhibitors (SRIs) show only partial reduction of symptoms
Since the introduction of minocycline HCl in the late 1960's, it has been Hovione has completed a Phase 2 clinical trial of 0
Early-phase schizophrenia patients were recruited and In our primary BeneMin trial , minocycline had no overall effect on levels of TNF-α or other cytokines or symptoms, nevertheless, the present results suggest that minocycline may modify cytokine The purpose of this study was to collect safety, tolerability, and pharmacokinetic (PK) data on ascending dose regimens of Minocin (minocycline) for Injection
It is a controlled trial of minocycline, an antibiotic commonly used in children for infection or for treatment of neurodegenerative disorders
Participants had lead-in assessments prior to the initiation of oral minocycline 100 mg twice daily for 12 DOI: 10
042 Corpus ID: 46868638; Efficacy and tolerability of minocycline for depression: A systematic review and meta-analysis of clinical trials
Methods Literature search spanned through November 30, 2017 across major databases Minocycline is a second-generation tetracycline antibiotic with good central nervous system penetration and anti-neuroinflammatory effect
, those who can show a therapeutic benefit from the anti-infective therapy
Participants were recruited from January 2016 to August 2020 at 9 university hospitals that served as study sites
Minocycline treatment for 3 months in children with FXS resulted in greater global improvement than placebo
Participants were recruited into a double-blind randomized clinical trial from May 23, 2014, to April 14, 2016, with 24 months of treatment and follow-up
Phase 4 trials look at long-term safety and effectiveness, after a new treatment has been approved and is on the market
Fifty patients with peri-implantitis were recruited, and surgical treatment with the local application of either minocycline or placebo ointment was performed
Minocycline, a semisynthetic derivative of tetracycline, has the same clinical
On the basis of encouraging preliminary results, we conducted a
trial to determine whether minocycline reduces the risk of conversion from
Study Design and Methods
Abstract Background: On the basis of encouraging preliminary results, we