This may explain why neurologic symptoms start emerging around these levels
The therapeutic range for total valproic acid (bound and unbound) has been established at 50-125 µg/mL and 6-22 µg/mL for free valproic acid (unbound only)
The generally acceptable range for total valproic acid used as a reference to guide therapy is 50 to 125 mcg/mL
Peak levels should not exceed 125 mcg/mL
The generally accepted therapeutic range for total valproic acid steady-state concentrations is 50–100 μg/mL, although some clinicians suggest drug concentrations
Usual effective plasma concentrations range from
The usual dose for treating epilepsy for: adults and older children (aged 12 years and over) – 600mg to 2,000mg a day, split into 2 to 4 doses
To interpret test results use the reference range in the laboratory report
The valproic acid test is done to monitor the concentration of valproic acid in the blood and to detect low or excessive (potentially toxic) concentrations
Detailed Valproic Acid dosage information for adults and children
If you have questions about the valproic acid test, or what the test results mean, speak with your doctor
50 to 120 µg/mL
4 With a daily dose of more than 500 mg, plasma concentrations may not increase proportionately because clearance increases with an increase in
Find a Test; Valproic Acid Valproic Acid « Find Another Test; Update Type: Reference range changed Usage
Please refer to the original patient
Valproic Acid Print Range Range Unit : Years: 99 Years: Normal: 50 - 100: ug/mL : Years: 99 Years: Urgent > 150: ug/mL: Special Info
Adults and children can take valproic acid to treat bipolar disorder or epilepsy
The typical range of Valproic acid should be kept within a therapeutic range
Valproic Acid, Free
Interpretive Data: Free valproic acid may be important to monitor in patients with altered or unpredictable protein binding
Valproic Acid - Valproic acid is used as an anticonvulsant to treat certain types of seizures, to prevent migraine headaches and to treat various psychiatric illnesses such as bipolar disorder and aggression
Valproic acid (VPA) often is used to treat mania in bipolar disorder, and it has a therapeutic range of 50 to 125 µg/mL of total serum concentration
The therapeutic range for Valproic acid is 50-100 mcg/ml, above which it is toxic
Test Mnemonic
Descriptions
Clinical laboratory test: Normal value: Valproic acid, blood n: 350–700 µmol/L: Vitamin B 12, blood f: 133–675 pmol/L: 75–250 nmol/L: a Eastern Ontario Regional Laboratory Association
Valproic acid (2-propylpentanoic acid; VPA) is a branched-chain carboxylic acid introduced as an anti-epileptic drug in 1978 in the United States
Sample stability: 2 days at 20-25 o C 7 days at 4-8 o C 3 months at -20 o C 4