If you are pregnant and have taken ondansetron or Zofran® during pregnancy, I want to reassure you that it likely has not affected your baby
Ondansetron has minimal efficacy against nausea and vomiting caused by motion sickness, mediated by different
Background: Ondansetron is a selective antagonist of the serotonin 5-HT3 receptor that is commonly used to treat morning sickness
Maximum dose: 16 mg per dose
Then administer 8 mg twice a day (every 12 hours) for 1 to 2 days after completion of chemotherapy
There are no concerns that ondansetron use in pregnancy affects the chance of miscarriage, stillbirth, preterm delivery or low infant birth weight
Subacute intestinal obstruction — ondansetron increases large bowel transit time
Controlled studies in pregnant women show no evidence of fetal risk
Sakran R, et al
1 Despite lack of United States Food and Drug Administration approval for indicated use in pregnancy, the most common treatment for nausea and vomiting of pregnancy (NVP) in the USA is ondansetron
Answer
This means that the number of babies born with cleft palate increased from 11 per 10,000 to 14 per 10,000)
In a paper published online in JAMA, the team reports no
Ondansetron is a selective serotonin receptor antagonist that prevents nausea and vomiting associated with chemotherapy, radiotherapy, and surgery and is commonly used to treat morning sickness ()
Was still hypersensitive to smell, etc
It cites limited data from small studies that ondansetron is equally effective but has fewer adverse effects compared with metoclopramide, and is more effective at Ondansetron taken during pregnancy was not associated with a significantly increased risk of adverse fetal outcomes